The Interstitial Geometry Hypothesis

Do Biological Structures Exploit Hidden Topologies Between Molecules for Communication?

In the vast and intricate landscape of molecular biology, much attention has been given to the molecular entities themselves—proteins, lipids, nucleic acids. But little consideration is given to the "space between"—the interstitial geometries of living tissue. This article proposes a novel hypothesis: that biological systems exploit the nanoscale topology of interstitial spaces—not just as a passive byproduct of molecular arrangement, but as an active medium for information transfer and structural computation.

This hypothesis suggests that the spatial voids between molecules in dense biological matrices (such as cytoplasm, extracellular matrix, or lipid bilayers) exhibit non-random geometrical configurations that can be modulated and interpreted by cells, akin to a hidden syntax of volumetric resonance.